Circulating immune complexes and disease activity in Crohn's disease.

Circulating immune complexes and disease activity in Crohn's disease.

Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was 63% and 61% at first testing, 85% and 78% at subsequent determinations; there...

Circulating immune complexes in lung disease.

Circulating Immune Complexes in Lung Disease H ypersensitivity lung diseases, of which allergic aspergillosis is a prototype, are an immunologic curiosity. Organisms usually of little virulence grow in plugs of airway mucus. These organisms are protected by the mucous matrix which seems to serve as an adjuvant. The ensuing brisk immunologic response is ineffective in clearing the bronchial tree...

Circulating Immune Complexes in Atherosclerotic Vascular Disease

Inflammatory bowel disease associated circulating immune complexes.

Circulating immune complexes have been detected in patients with inflammatory bowel disease (IBD). To determine if these complexes are related specificially to IBD or more generally to loss of intestinal mucosal integrity, we compared circulating immune complex levels in the sera of 86 IBD patients, nine pseudomembranous and nine bacterial colitis patients, and 42 healthy controls. Immune compl...

Evidence for circulating immune complexes in thyroid disease.

Anti-complementary activity was detected in the sera of 23 (59%) out of 39 patients with Hashimoto thyroiditis; in 10 (29%) out of 34 patients with primary hypothyroidism; in six (17%) out of 36 patients with thyrotoxicosis; and in only six (8%) out of 78 control subjects. Fractionation of Hashimoto sera by Sephadex G-200 chromatography showed that the anti-complementary activity was founding f...